Mayo Clinic’s CT Clinical Innovation Center has been part of a journey that spanned more than a decade. Partnering with Siemens Healthineers, the first human whole-body, high-flux photon counting CT system was installed at Mayo in 2014. Another prototype was installed in 2020, and today the system installed in April 2021, the NAEOTOM Alpha, has received 510k FDA clearance. Photon counting CT is now a clinical reality! Congratulations to all who have been a part of this journey!